Clinical Studies

Pre-clinical and clinical studies have proven that periodic fasting, done for several consecutive days, is a very powerful intervention that our bodies learned to naturally cope with by protecting and rejuvenating itself. These two factors are both anti-aging measures that offer additional health benefits. The ProLon® Fasting Mimicking Diet® has been clinically tested and found to promote beneficial effects in a wide variety of conditions ranging from excess weight and fasting blood glucose, to growth factors associated with DNA damage and aging.

Clinical Study Methodology

Randomized controlled trial of 100 subjects, 71 completed three cycles of the ProLon® either in a randomized phase (N=39) or after being crossed over from a control diet group to the FMD group (N=32). Control subjects continued their normal diet. ProLon participants consumed the Fasting Mimicking Diet (FMD) for five consecutive days per month for three months. Measurements were performed prior to the diet (before) and during the recovery period after the 3rd cycle (after).

Min Wei; Sebastian Brandhorst et al.
Fasting‐Mimicking Diet and Risk Factors for Aging, Diabetes, Cancer and Cardiovascular Disease.
Science Translational Medicine February 15, 2017

Clinical Trial Results

Body Weight

-5.7 Lbs.

Weight loss came mostly from
abdominal fat. Participants lost
an average of 5 lbs.

Blood Pressure

_ _ _

Systolic and diastolic blood
pressure was reduced from
118 to 113.5 mm Hg (systolic)
and 75.7 to 72.6 mm Hg (diastolic).

Waist Circumference

-1.6 In.

1-inch loss in waist
circumference. While lean
body mass was preserved.

Elevated Risk Cohort Results

Body Weight

-9 Lbs.

In obese participants (BMl>30),
body weight decreased 9 lbs.
Weight remained significantly
lower after subjects returned to
their normal diet for an average
of 3 months.

Abdominal Fat


In overweight participants
(BMl>25), abdominal fat was
reduced by >7%.

Waist Circumference

-3 cm

With preserved relative lean
body mass and decreased
waist circumference by
approximately >3 cm.

Blood Pressure

_ _ _

For participants with high blood
pressure (>120/80) systolic and
diastolic BPs were reduced by
>6 mmHg.