Frequently Asked Questions

Get answers to some of the most common questions

ProLon® is the first Fasting Mimicking Diet™ (FMD™) developed to provide the beneficial effects of fasting by making the fasting mimicking period safe and pleasant. ProLon®, which contains plant-based soups, bars, crackers, olives, drinks, and supplements, is a proprietary 5-day dietary program, providing approximately 750 to 1100 calories per day. It is based on innovative research carried out at two of the world’s leading centers for biomedical and longevity research located at the University of Southern California (USC), the Longevity Institute and the Diabetes and Obesity Research Institute. This revolutionary meal plan has been scientifically designed and clinically tested to mimic the effects of fasting, while providing the proper daily nourishment and the feeling of satisfaction.

ProLon® was shown in clinical trials to have beneficial effects on a wide variety of markers: it decreases abdominal fat while increasing relative lean body mass, decreases fasting glucose, reduces C-reactive protein, and reduces IGF-1

A Fasting Mimicking and Enhancing™ Diet (FMED™) is a high nutrition, low protein, low carbohydrate meal plan, clinically proven to beneficially change a wide range of biomarkers. (See Question 2).

The diet should be used for 5 consecutive days per month (30 days) after which the patient will transition for 1 day and then resume their normal diet. Instructions are provided in every carton. A specific combination of food is provided on each day for breakfast, lunch, dinner and snacks. All food provided on a specific day should be taken on that day only. While a meal missed can be made up at any time during the same day, there should be no carryover from one day to the next. The 5-day diet should be taken as often as is recommended by the healthcare professional.

The amount of weight loss varies by individual. A healthcare professional will be able to discuss this during consultation and work with the patient on meeting weight goals.

Depending on the medical illness or disease, past medical history, and current medications, the ProLon® dietary program might be combined with the standard of care treatment; however, ProLon® cannot be prescribed to prevent or treat diseases. Contact the healthcare provider most familiar with the illness or disease to discuss the ProLon® dietary program.

As the ProLon® dietary program is designed to provide all of the supplements and nutrients needed, no additional multivitamins or supplements should be taken during the diet period; however, the options should be discussed with the supervising healthcare professional.

The ProLon® dietary program should be administered under the supervision of a licensed healthcare professional (HCP), e.g. Medical Doctor, Doctor of Osteopathic Medicine, Physician Assistant, Nurse Practitioner, a Doctor of Integrative Medicine, Anti-Aging Specialist, Naturopath, Chiropractor or Registered Dietitian. As this is a low calorie diet, that supervising HCP must clear the individual to participate in the program. If the HCP does not feel qualified to clear the patient, they should seek clearance from a qualified HCP, such as a medical doctor. In addition, they should determine if the individual has any known medical conditions, and if so, obtain medical clearance from the HCP treating the patient’s condition before initiating the ProLon® diet.

Healthcare professionals who desire to sell or authorize patients to purchase ProLon® must first register on this website. This is an easy, one-time process.
Once you are registered you will be able to order, refill orders or authorize patients to purchase ProLon® from the website.

There are three ways that a non-health care professional can order Prolon:

1. In order to obtain ProLon®, an individual should first take our Health Self-Assessment Survey to determine if ProLon® is appropriate for you and whether you can purchase it now, or you need to have a physician consultation. If it is determined that clarification is needed based on the responses in your self-assessment, you will be asked to consult with a physician before purchasing ProLon®. However, if after completing the survey no further clarification is required, then the final step before shipping your order will be scheduling and having a call with a dietitian or nurse practitioner for guidance on the ProLon® diet.

2. Health Care Provider Evaluation: See either your own doctor to discuss if ProLon® is right for you, or use our free telemedicine doctor consulting service. CLICK HERE for more information on arranging for that doctor consultation.

3. Use HCP Authorization Code from Health Care Provider: Once you have healthcare provider approval, you will use the approval code the practitioner provides you to complete the registration and order ProLon® for yourself.

During the consultation with potential ProLon® users, the supervising healthcare professional should determine if a low calorie and low protein diet lasting 5 days would be safe for patients based on their medical history and health conditions. The supervising physician should educate the patient about potential side effects, and provide contact information to enable the patient to contact him/her if any medical condition arises. Also, the healthcare provider might consider following up with the participants during the ProLon® diet cycle to ensure that patients are following the diet correctly. (See Question 14.)

The ProLon clinical trials protocol included three consecutive cycles of ProLon (5-day only per month over three consecutive months). It is up to the practitioner to decide the best protocol that he or or she would like to use for each patient. We suggest that for patients who are obese or overweight, they use ProLon for one three cycle protocol, and recommend that you as their doctor check in with patient to re-assess and determine if they have met their goals or if more cylces would be helpful. If a patient is not overweight and eats and exercises well, we suggest the product 1-2 times a year

Splitting up days is not recommended since this method is believed to be much less effective than the 5 consecutive days.

On Day 6, after the ProLon® diet ends, users should avoid binge eating and resume their normal diet gradually. They should start with liquid foods, such as soups and fruit juices, followed by light meals, including rice, pasta and small portions of meat, fish and/or legumes. A normal diet can be resumed on day 7, or 24 hours after the end of the ProLon® diet.

The results achieved with ProLon® in clinical trials were very similar to those achieved with fasting. However, ProLon® is safer, providing vital nutrition during the 5 day diet.

The proprietary dietary formulation is based on decades of scientific research, including preclinical and clinical trials and contains specific ingredients that were put together to mimic fasting, while optimizing nourishment.

The healthcare professional (HCP) should make recommendations based on the individual; however, the patient may want to record their weight, blood pressure, and abdominal circumference before starting and after each cycle of the diet. Also, the HCP may want to remind the patient to take the diet as planned, but if they miss something to record that and inform the HCP. Someone who wants to track their calorie intake and other parameters might want to try the app “Lose It” (

The meal plan contains some products that are made with organic ingredients, but they are not certified organic. Our food products are all plant based.

As the ProLon® dietary program provides all one needs for nourishment during the 5 days, while letting the powerful self-repair and rejuvenation mechanisms work, no extra foods or drinks (other than water and decaffeinated tea) should be consumed while on ProLon® to avoid reducing its efficacy.

One should not eat anything extra while on the ProLon® dietary program. Since this diet is low calorie, one may experience the feeling of slight weakness and possible dizziness as the body adjusts, especially on Day 2. This is normal. Usually by day 3 this decreases; however, should the symptoms be severe, one can drink fruit juices and call your doctor or 911 for emergencies. The supervising healthcare professional should then review if it is safe for the patient to continue on the diet. The energy drink provided in the diet boxes, to be taken throughout the day, provides not only nutritional support during the diet, but can be specifically helpful in these instances.

Because the ProLon® diet is low in calories, hunger may occur during the 5 day diet period. Most clinical trial participants only experienced a low level of periodic hunger. If hunger is severe, the patient should contact their healthcare professional. In such cases, one may want to consume a food that is not highly caloric, such as a slice of an apple. Remember, this diet is only for 5 days. Feeling hungry is normal if one’s normal diet consists of high calories. People generally reported that the hunger subsided by day 3 or 4.

Because coffee can interfere with the beneficial effects of the diet, it is not recommended to be consumed with ProLon®. However, if one must have coffee, we recommend minimizing coffee consumption to 1 cup per day.

There are different flavors of teas provided with the diet. Although not recommended, since the ProLon® teas are selected for specific properties and have been clinically tested, if for some reason one does not want to consume one of these flavors, a substitution can be made. A substitute tea should have no caffeine or additives, and should be taken without sugar or cream.

Yes; however, since this diet has been clinically tested, one should make every effort to follow the program to minimize malnourishment and safety issues. Just document the foods not eaten and inform the supervising healthcare professional.

Yes, if a meal is missed, it can be taken later on the same day; but do not take a missed meal on a different day. (See Question 26.)

This is not advised; the foods provided should only be consumed on the day for which they are designated; however, if feeling lightheaded, dizzy or having any other side effects, consuming one of the leftover diet foods would be preferable to consuming something else. Note: the ProLon® diet does not have extras in the meal box. (See Question 20.)

The positive effects of the ProLon® dietary program tested in the clinical trials require 5 consecutive days. Therefore, the diet should be maintained for the full 5 days. If the diet must be discontinued earlier, however, the healthcare professional should be informed.

The diet is formulated based on specific nutritional, scientifically proven benefits. Therefore, it’s very important to follow the diet closely. However, if this happens on one occasion, do not worry—continue with the ProLon® dietary program for the rest of the 5 days.

It depends on the food item. For example, if a soup is disliked, lemon/lime and herbs can be added in small quantities. If a tea is disliked, a different tea can be substituted, provided it is non-caffeinated, non-sugared, preferably with no added color or preservatives.

Yes, herbs and lemon in small quantities may be added to taste. Please note that the diet is specially formulated to provide a specific amount of nutrients and calories.

DHA stands for docosahexaenoic acid and is an omega-3 fatty acid. DHA is essential for normal brain function.

The energy drink is specially formulated to provide vegetable-based nutritional support during the diet.

The energy drink is made from plant-derived glycerol and water. This selection is the result of years of studies to maximize safety and nourishment without interfering with the beneficial effects of the diet.

ProLon® Fasting Mimicking Diet is Lactose and Gluten Free. Individuals with allergies to nuts, soy or tomato should avoid consuming the current version of ProLon®.

We recommend you discuss your ongoing diet with your healthcare professional. They can review your current intake and give you specific guidelines to follow based on your height, weight and gender. During the 5 day ProLon® dietary program, approximately 1100 calories are consumed on Day 1 and 750 calories on Days 2-5.

Patients can buy multiple boxes of ProLon® at one time and receive quantity discounts. Each box contains everything needed for the 5-Day cycle.  All the ProLon® boxes ordered will be shipped at one time.  If the individual decides not to continue with ProLon®, as long as the remaining boxes were never opened, the remaining boxes may be returned within 30 days of purchase for a full refund—minus the quantity discount that he/she would no longer qualify for. Refunds for reasons other than damaged or expired product will be subject to a restocking fee of 15% of the price of each box.